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P1‐089: ADMINISTRATION OF BIFIDOBACTERIUM BREV E STRAIN A1 PREVENTS COGNITIVE IMPAIRMENT IN AN ALZHEIMER'S DISEASE MODEL MOUSE
Author(s) -
Kobayashi Yodai,
Shimada Kousuke,
Mitsuyama Eri,
Kuhara Tetsuya,
Yasuoka Akihito,
Kondo Takashi,
Abe Keiko,
Xiao Jin-zhong
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.091
Subject(s) - bifidobacterium breve , spontaneous alternation , probiotic , hippocampus , hippocampal formation , medicine , immune system , neuroinflammation , bifidobacterium , inflammation , disease , pharmacology , immunology , endocrinology , biology , lactobacillus , genetics , bacteria
diet. Notably, some components of EVOO (oleuropein and oleoncanthal) have shown to hold potential as tau-modifying compounds, preventing tau fibrillization and aggregation in vitro but no in vivo data are available. Methods: Herein, we investigated whether chronic administration of EVOO modulates the development of the pathological phenotype of a relevant mouse model of pure tauopathy, the h-Tau mice. Starting at 6 months of age, animals were randomized into two groups, one receiving regular chow and one receiving chow diet supplemented with EVOO for 6 months and at the end of the treatment animals underwent three behavioral tests the Y-maze, Novel object recognition and Morris water maze. Results: At the end of the treatment no significant differences between the two groups in terms of body weight and motor function were observed. By contrast, we found that, compared with h-Tau mice receiving vehicle the one chronically treated with EVOO-rich diet had a significant improvement of both working and spatial memory as well as short-term recognition memory. Neuropathological assessments looking at tau phosphorylation, synaptic integrity as well as neuroinflammation are being performed. Conclusions: Our findings demonstrate that long-term consumption of EVOOenriched diet provides a protective effect against impairment of hippocampal-dependent memory in the h-Tau mouse model of tauopathy. They support the novel hypothesis that EVOO could be considered as a beneficial natural product against Tauopathies.