Premium
P1‐030: ENVIRONMENTAL DETERMINANTS OF NEUROANATOMIC RISK FOR ALZHEIMER'S DISEASE IN OLDER WOMEN: ROLE OF FINE PARTICULATE MATTER
Author(s) -
Younan Diana,
Wang Xinhui,
Petkus Andrew J.,
Casanova Ramon,
Barnard Ryan,
Gaussoin Sarah A.,
Saldana Santiago,
Resnick Susan M.,
Serre Marc,
Vizuete William,
Shumaker Sally A.,
Gatz Margaret,
Chang Chui Helena,
Espeland Mark A.,
Chen Jiu-Chiuan
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.031
Subject(s) - neuropathology , parahippocampal gyrus , neurodegeneration , biomarker , neuroscience , temporal lobe , medicine , alzheimer's disease , neuroimaging , psychology , disease , biology , epilepsy , biochemistry
in self-reported CA over time on global cognition in older adults without mild cognitive impairment or dementia. Methods: Participants were 742 older adults from the RushMemory and Aging Project, an ongoing epidemiological cohort study. Participants were recruited from Chicago communities, and agreed to annual clinical evaluations, including neurocognitive testing and wearing an accelerometer for 10 days. Exclusion criteria included diagnosis or symptoms of mild cognitive impairment or dementia. Longitudinal data with 3-5 time points were used, with the first time point being the first assessment with both accelerometer and neurocognitive data. A parallel growth model tested the interaction between change over time in PA (mean daily accelerometer counts) and change over time in CA (self-report of seven activities) on global cognition (index of 19 neurocognitive tests). Results:Higher levels of baseline PA (p<.001) and baseline CA (p<.001) were each related to higher global cognition at five years. Increases in CA over time were significantly related to higher global cognition (p<.001), but change in PA over time was unrelated to global cognition. The interaction between change in PA and change in CA over time was significantly related to higher global cognition (p<.001) such that the positive effects of changes in CAwere stronger among those who had increases in PA over time. Conclusions: These findings suggest the importance of considering changes in both PA and CA over time in order to prevent cognitive decline in older adults. PA and CA show evidence of synergistic effects on cognition, which should be further explored in trials with factorial designs of multi-domain interventions.