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P1‐029: THE INTERACTIVE EFFECTS OF CHANGES IN PHYSICAL ACTIVITY AND COGNITIVE ACTIVITY ON GLOBAL COGNITION IN OLDER ADULTS WITHOUT MILD COGNITIVE IMPAIRMENT OR DEMENTIA
Author(s) -
Halloway Shan,
Schoeny Michael E.,
Wilbur JoEllen
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.030
Subject(s) - neurocognitive , dementia , cognition , longitudinal study , cognitive decline , psychology , gerontology , medicine , cohort , physical medicine and rehabilitation , disease , psychiatry , pathology
Occupational Information Network (O*NET) database, and tested whether it moderates effects of genetic risk and biomarkers of AD pathology on cognitive function in two independent studies of ageing and AD. Methods:We applied growth curve modelling to longitudinal data from a population based cohort (AgeCoDe, n1⁄42369) of non-demented individuals above age 75 at baseline to test whether higher OCR would attenuate APOE4 associated cognitive decline. In addition, we used data of n1⁄4317 participants of the DELCODE study (123 healthy controls, 96 with Subjective Cognitive Decline, 52 MCI, 25 AD dementia, 21 cognitively normal relatives of AD dementia patients; mean age 1⁄470.2 (SD1⁄45.9)). We tested with regression analyses whether higher OCR moderate the cross-sectional association between hippocampal volume and CSFAD biomarkers with performance in 5 cognitive domain scores derived from confirmatory factor analysis of an extensive neuropsychological test-battery. To operationalize OCR, we linked individual’s detailed lifetime occupation information to O*NET data according to the method of Poole et al. (2016). This method summarizes ratings of cognitive demands in 10 workrelated tasks (e.g. processing information, thinking creatively). Results: In AgeCoDe, detrimental effects of ApoE4 on cognitive decline in the MMSE were significantly attenuated for those with high OCR scores (Figure 1). Similarly, in DELCODE the expected cross-sectional associations of lower hippocampal volume and more pathological CSFAbeta42/Tau ratiowith a decrease in cognitive performance were significantly less pronounced in those with higher OCR scores (Figure 2). Results remained similar after adjustment for educational level. Conclusions: We observed moderating effects of OCR on the association of genetic risk and AD biomarkers with cognition. These results provide important, novel evidence that OCR contribute to cognitive reserve in late-life. In addition, they validate the recently developed, O*NET based operationalization of this protective factor with data from two independent cohorts.