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P1‐023: MASS SPECTROMETRY–BASED MEASUREMENT OF LONGITUDINAL CSF TAU IDENTIFIES DIFFERENT PHOSPHORYLATED SITES THAT TRACK DISTINCT STAGES OF PRESYMPTOMATIC DOMINANTLY INHERITED AD
Author(s) -
Barthélemy Nicolas R.,
Li Yan,
Wang Guoqiao,
Fagan Anne M.,
Morris John C.,
Benzinger Tammie L.S.,
Goate Alison,
Hassenstab Jason,
Xiong Chengjie,
Sato Chihiro,
Bateman Randall J.,
McDade Eric
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.024
Subject(s) - cerebrospinal fluid , phosphorylation , chemistry , medicine , mutation , pathology , biochemistry , gene
exosomes isolated from injected mice contained human tau species as measured by ELISA, suggesting exosome trafficking from the CNS to the periphery. Conclusions: Here, we are the first to demonstrate that secreted exosomes isolated from hiPSCs can propagate human tau and oAb species to multiple brain regions and traffic into the periphery. Our model system provides a means to study transcellular propagation of exosome cargo, and related neurodegenerative mechanisms. Together, our data suggests that exosomes are mediators of AD pathogenesis and can serve as potential targets for AD therapeutics.