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P1‐010: IN‐BOUND BUT NOT OUT‐BOUND SOCIAL CONNECTEDNESS MODERATES THE EFFECT OF AGE‐RELATED WHITE MATTER PATHOLOGY ON VERBAL FLUENCY
Author(s) -
Kwak Seyul,
Joo Won-tak,
Youm Yoosik,
Chey Jeanyung
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.011
Subject(s) - psychology , verbal fluency test , centrality , cognitive decline , fluency , cognition , developmental psychology , medicine , dementia , neuropsychology , disease , pathology , psychiatry , mathematics , mathematics education , combinatorics
Background:Lipidomics has enabled a comprehensive investigation of blood lipid biomarkers in dementia. However, most studies have been cross-sectional and were thus more likely to reveal consequences of disease rather than etiological risk factors or very early biomarkers. Our objective was to prospectively identify, among older persons free of dementia, a blood lipid signature predictive of cognitive decline over 12 years following blood draw in a French population-based cohort (Three-City (3C) study).Methods:We built a case-control study of cognitive decline nested in 3C Bordeaux, including non-demented participants with blood sampling at baseline and with repeated cognitive testing over 12y. Our primary outcome was the change in global cognition (composite score of 5 normalized psychometric tests). We used linear mixed models to identify the 220 participants with worse