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Sleep disturbances and dementia risk: A multicenter study
Author(s) -
Sindi Shireen,
Kåreholt Ingemar,
Johansson Lena,
Skoog Johan,
Sjöberg Linnea,
Wang HuiXin,
Johansson Boo,
Fratiglioni Laura,
Soininen Hilkka,
Solomon Alina,
Skoog Ingmar,
Kivipelto Miia
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.05.012
Subject(s) - dementia , odds ratio , insomnia , hazard ratio , confidence interval , medicine , longitudinal study , gerontology , psychiatry , disease , pathology
Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Methods Sleep disturbances were assessed in three population‐based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late‐life baseline analyses (3–10 years follow‐up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow‐up) (N = 1407). Results Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02–1.50) and late‐life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08–3.49) were associated with a higher dementia risk. Late‐life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87–8.48). Discussion Midlife insomnia and late‐life terminal insomnia or long sleep duration were associated with a higher late‐life dementia risk.