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Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment
Author(s) -
Yoo Han Soo,
Jeon Seun,
Chung Seok Jong,
Yun Mijin,
Lee Phil Hyu,
Sohn Young Ho,
Evans Alan C.,
Ye Byoung Seok
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.05.010
Subject(s) - lewy body , dementia , psychology , white matter , neuroscience , atrophy , olfactory system , alzheimer's disease , orbitofrontal cortex , disease , audiology , cognition , medicine , magnetic resonance imaging , pathology , prefrontal cortex , radiology
Olfactory dysfunction is common in Alzheimer's disease– and Lewy body–related disorders, but its neural correlates have not been clearly elucidated. Methods We retrospectively recruited 237 patients with Alzheimer's disease–related cognitive impairment (ADCI) and 217 with Lewy body–related cognitive impairment (LBCI). They were identically evaluated using the Cross‐Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. Results LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross‐Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. Discussion Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.