Premium
Helicobacter pylori and the risk of dementia: A population‐based study
Author(s) -
Fani Lana,
Wolters Frank J.,
Ikram M. Kamran,
Bruno Marco J.,
Hofman Albert,
Koudstaal Peter J.,
Darwish Murad Sarwa,
Ikram M. Arfan
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.05.005
Subject(s) - dementia , hazard ratio , medicine , helicobacter pylori , rotterdam study , cohort study , population , cohort , incidence (geometry) , confidence interval , immunology , disease , environmental health , physics , optics
Helicobacter pylori infection might increase risk of dementia, but available evidence is inconsistent, and longitudinal studies are sparse. We investigated the association between H. pylori serology and dementia risk in a population‐based cohort. Methods Between 1997 and 2002, we measured H. pylori serum IgG titers in 4215 nondemented participants of the Rotterdam Study with a mean age of 69 years. We determined the association between H. pylori at baseline and dementia incidence until 2015, per natural log (U/mL) increase in titer, and for seropositive/seronegative, using Cox models adjusting for cohort, sex, age, education, and cardiovascular risk factors. Results During a median follow‐up of 13.3 years, 529 participants developed dementia, of which 463 had Alzheimer's disease. H. pylori was not associated with risk of dementia (hazard ratio [95% confidence interval] for antibody titer: 1.04 [0.90–1.21]; for seropositivity 1.03 [0.86–1.22]), or Alzheimer's disease. Discussion In this community‐dwelling population, H. pylori was not associated with dementia risk.