Premium
PET staging of amyloidosis using striatum
Author(s) -
Hanseeuw Bernard J.,
Betensky Rebecca A.,
Mormino Elizabeth C.,
Schultz Aaron P.,
Sepulcre Jorge,
Becker John A.,
Jacobs Heidi I.L.,
Buckley Rachel F.,
LaPoint Molly R.,
Vannini Patrizia,
Donovan Nancy J.,
Chhatwal Jasmeer P.,
Marshall Gad A.,
Papp Kathryn V.,
Amariglio Rebecca E.,
Rentz Dorene M.,
Sperling Reisa A.,
Johnson Keith A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.04.011
Subject(s) - striatum , amyloid (mycology) , positron emission tomography , neuroscience , amyloidosis , cortex (anatomy) , dementia , psychology , hippocampal formation , pet imaging , hippocampus , pathology , cognition , pittsburgh compound b , medicine , cognitive impairment , disease , dopamine
Amyloid positron emission tomography (PET) data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a three‐stage PET classification: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid; hypothesizing this model could better reflect Alzheimer's dementia progression than a model based only on cortical measures. Methods We classified PET data from 1433 participants (646 normal, 574 mild cognitive impairment, and 213 AD), explored the successive involvement of cortex and striatum using 3‐year follow‐up PET data, and evaluated the associations between PET stages, hippocampal volumes, and cognition. Results Follow‐up data indicated that PET detects amyloid first in cortex and then in striatum. Our three‐category staging including striatum better predicted hippocampal volumes and subsequent cognition than a three‐category staging including only cortical amyloid. Discussion PET can evaluate amyloid expansion from cortex to subcortex. Using striatal signal as a marker of advanced amyloidosis may increase predictive power in Alzheimer's dementia research.