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Understanding the impact of sex and gender in Alzheimer's disease: A call to action
Author(s) -
Nebel Rebecca A.,
Aggarwal Neelum T.,
Barnes Lisa L.,
Gallagher Aimee,
Goldstein Jill M.,
Kantarci Kejal,
Mallampalli Monica P.,
Mormino Elizabeth C.,
Scott Laura,
Yu Wai Haung,
Maki Pauline M.,
Mielke Michelle M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.04.008
Subject(s) - call to action , disease , dementia , action (physics) , presentation (obstetrics) , psychology , gerontology , medicine , pathology , physics , marketing , business , radiology , quantum mechanics
Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches. Methods The Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD. Results The current review is a result of this Network's efforts and aims to: (1) highlight the current state‐of‐the‐science in the AD field on sex and gender differences; (2) address knowledge gaps in assessing sex and gender differences; and (3) discuss 12 priority areas that merit further research. Discussion The exclusion of sex and gender has impeded faster advancement in the detection, treatment, and care of AD across the clinical spectrum. Greater attention to these differences will improve outcomes for both sexes.