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Apolipoprotein E genotypes and longevity across dementia disorders
Author(s) -
Skillbäck Tobias,
Lautner Ronald,
Mattsson Niklas,
Schott Jonathan M.,
Skoog Ingmar,
Nägga Katarina,
Kilander Lena,
Wimo Anders,
Winblad Bengt,
Eriksdotter Maria,
Blennow Kaj,
Zetterberg Henrik
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.02.003
Subject(s) - dementia , apolipoprotein e , allele , vascular dementia , genotype , alzheimer's disease , longevity , medicine , disease , biomarker , oncology , psychology , gerontology , genetics , biology , gene
The ε4 allele of the apolipoprotein E ( APOE ) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter ( P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers ( P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. Discussion The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.