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Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta‐analysis
Author(s) -
Wolters Frank J.,
Segufa Reffat A.,
Darweesh Sirwan K.L.,
Bos Daniel,
Ikram Mohammad Arfan,
Sabayan Behnam,
Hofman Albert,
Sedaghat Sanaz
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.01.007
Subject(s) - dementia , medicine , meta analysis , relative risk , heart failure , confidence interval , cardiology , population , risk factor , disease , environmental health
Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods We systematically reviewed the literature and meta‐analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07–1.50]), albeit with considerable heterogeneity across studies (I 2 = 80%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19–2.13]) with moderate heterogeneity (I 2 = 59%). Among prospective population‐based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], nine studies; and HF, RR 1.80 [1.41–2.31], four studies) and highly consistent (I 2 = 0%). Conclusion CHD and HF are associated with an increased risk of dementia.