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Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
Author(s) -
Rosenberg Anna,
Ngandu Tiia,
Rusanen Minna,
Antikainen Riitta,
Bäckman Lars,
Havulinna Satu,
Hänninen Tuomo,
Laatikainen Tiina,
Lehtisalo Jenni,
Levälahti Esko,
Lindström Jaana,
Paajanen Teemu,
Peltonen Markku,
Soininen Hilkka,
StigsdotterNeely Anna,
Strandberg Timo,
Tuomilehto Jaakko,
Solomon Alina,
Kivipelto Miia
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.09.006
Subject(s) - dementia , medicine , socioeconomic status , cognition , population , gerontology , randomized controlled trial , intervention (counseling) , cognitive decline , body mass index , neuropsychology , physical therapy , psychiatry , environmental health , disease
The 2‐year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Methods The FINGER recruited 1260 people from the general Finnish population (60–77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z‐score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed‐model repeated‐measures analyses. Results Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini–Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention ( P ‐values for interaction > .05). Conclusions The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.