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[P4–581]: BROMO‐PROTOPINE, A NOVEL DERIVATIVE OF PROTOPINE WITH IMPROVED BIOAVAILABILITY AND BIOACTIVITY, DEGRADES TAU AGGREGATION THROUGH MODULATION OF HDAC6‐HSP90 CHAPERONIC ACTIVITY AND IMPROVES MEMORY VIA STIMULATION OF THE RAS‐GRF1/ERK PATHWAY
Author(s) -
Kumar Durairajan Siva Sundara,
Reddy Rambabu,
Shetty Sravan Gopalakrishnan,
Iyaswamy Ashok,
Kammella Ananth Kumar,
Krishnamoorthi Senthil Kumar,
Zhang Hongjie,
Li Min
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.744
Subject(s) - chemistry , pharmacology , in vivo , hdac6 , bioavailability , hsp90 , biochemistry , heat shock protein , biology , histone , microbiology and biotechnology , histone deacetylase , gene