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[P4–579]: BREAKTHROUGH IN DEMENTIA/ALZHEIMER's DISEASE THERAPY: THREE DIFFERENT CASES OF ENERGY TREATMENT WITH DELAYED AND SUSTAINED RELEASE OF GLUCOSE
Author(s) -
Xia Jun,
Cao Chuanhai,
Cao Annie
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.742
Subject(s) - dementia , bedtime , medicine , morning , disease , intensive care medicine , psychiatry
additional tests of episodic verbal memory and visuospatial working memory were developed and incorporated. Collection of censusmatched normative data in 750 healthy individuals is currently underway. We describe preliminary findings comparing performance of young (<55) and older ( 55) healthy adults, as well as performance of individuals with subjective cognitive complaints. Methods: Tasks were designed in compliancewith guidance for objective psychometric tests (Ferris et al., 1997) and to enable tablet-assisted administration, automatic scoring, and data management in compliance with 21 CRF Part 11 requirements. Data currently includes 143 participants, including 63 healthy young adults (YA, <55 years), 76 healthy older adults (OA, 55 years), and 4 individuals with cognitive complaints. Participants with cognitive complaints were classified as such based on total scores of 4 on theMail-In Function Cognitive Screening Instrument (MCSFI). Results: Means and standard deviations are presented for YAs, OAs and cognitive complainers. OAs underperformedYAsonBACApp endpoints including verbal learning, verbal fluency, symbol coding, and token motor test (p<.01 for all). Although delayed recall did not reliably differ between healthy YAs (mean1⁄49.01, SD1⁄43.02) and OAs (mean1⁄48.38, SD1⁄43.26), cognitive complainers performed well below their normative counterparts (mean1⁄44.25, SD1⁄42.99). Visuospatial working memory performance showed significant decline in OAs as compared to YAs (p<.01), and preliminary data suggest increased decline in cognitive complainers. Conclusions: Preliminary findings suggest the BAC App is sensitive to age-related changes in cognition, and show potential sensitivity to differences between healthy OAs and those with subjective cognitive complaints. Enhancement of the BAC App with additional measures of episodicmemory and visuospatial workingmemory shows potential for increasing the utility of the measure in early MCI-AD.