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[P4–558]: IMPACT OF ALZHEIMER's DISEASE DEVELOPMENT ON THE HEART: FOCUS ON INFLUENCE OF PHYSICAL AND MENTAL ACTIVITY AGAINST THE DELETERIOUS EFFECT OF SOCIAL ISOLATION AND PROTEIN MALNUTRITION
Author(s) -
Ali Azza A.,
Hassan FatmaElzahraa M.,
Elnahhas Toqa M.,
AbuElfotuh Karema,
Ezzeldin Essam
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.721
Subject(s) - medicine , malnutrition , social isolation , disease , oxidative stress , mental health , gerontology , psychology , psychiatry
common analytic approach for accounting for spillover costs was to add informal caregiving time costs to patient costs (n1⁄432). Few studies included caregiver out-of-pocket costs in the analysis (n1⁄43). When spillover health effects were considered, most studies added informal caregivers’ QALYs to patient values (n1⁄410). Thirty three pairs of ICERs reported results with and without spillover effects. Incorporating spillover effects generally decreased ICERs (making them more favorable) (n1⁄416; 48%) or kept the intervention cost-saving (n1⁄413; 39%); and in fewer cases increased ICERs (n1⁄42; 6%) or produced no change (n1⁄42; 6%).Conclusions:Most dementia/AD CUAs incorporated spillover costs, often as time costs to a caregiver, but considered caregiver health impacts less often. Including spillover effects in analyses generally led to more favorable ICERs. The broader value of a dementia/AD intervention to society may be underestimated without considering these broader spillover effects.