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[P4–531]: TDP‐43 DRIVES FASTER RATES OF HIPPOCAMPAL ATROPHY IN ALZHEIMER's DISEASE STARTING AT LEAST 10 YEARS PRIOR TO DEATH
Author(s) -
Josephs Keith A.,
Dickson Dennis W.,
Tosakulwong Nirubol,
Murray Melissa E.,
Weigand Stephen D.,
Petrucelli Leonard,
Liesinger Amanda,
Senjem Matthew L.,
Spychalla Anthony J.,
Knopman David S.,
Parisi Joseph E.,
Petersen Ronald C.,
Jack Clifford R.,
Whitwell Jennifer L.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.693
Subject(s) - atrophy , hippocampal formation , neurofibrillary tangle , hippocampus , amygdala , pathology , alzheimer's disease , medicine , autopsy , neuroscience , psychology , disease , senile plaques
approximately 5 years between SUVR1⁄41.17 and SUVR1⁄41.35 (mean value for AD Ab+ participants). Regional analysis demonstrated spatially non-uniform tau accumulation, with a flat trajectory for the medial temporal region and sequentially increasing trajectories for lateral temporal, parietal and then frontal regions. Conclusions:Average long-term trajectories combining 139 longitudinal sequences of F-Flortaucipir images, obtained over a short 18-month interval, suggests an accelerated tau accumulation as Alzheimer’s Disease advances. This preliminary observation requires additional validation using independent datasets and further optimization of the applied methodology is warranted. Individual variability in trajectories is acknowledged; the average trajectories found in the present analysis may inform the construction of more individualized models.