Premium
[P4–522]: A NOVEL TOOL FOR QUANTIFICATION AND VISUALIZATION OF BRAIN ATROPHY: PROOF OF PRINCIPLE
Author(s) -
Gryska Emilia Agnieszka,
Klasson Niklas,
Heckemann Rolf A.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.684
Subject(s) - atrophy , dementia , frontotemporal dementia , voxel , psychology , magnetic resonance imaging , cognitive impairment , cardiology , audiology , medicine , cognition , nuclear medicine , neuroscience , disease , radiology
Figure 3. Regions of interest. Background:Monoclonal antibody targeting amyloid for removal from the brain appears to unmask cerebral amyloid angiopathy (CAA). This may result in Amyloid Related Imaging Abnormalities (ARIA). ARIA-E is defined as edema, best seen on flair MRI. ARIA-H is defined as hemorrhages best seen on GRE. Both appear related to same increases in vascular permeability. ARIAE occured in 10% of subjects treated with bapineuzumab, and half of these also developed ARIA-H, all MH’s, with correlation in both time and space. Methods:We report a case of serial MRI’s tracking ARIAwith a 7.5 year follow up MRI, the longest reported follow up thus far reported. Results:At 7.5 years, the patient had
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom