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[P4–502]: THE EARLIEST STAGES OF AMYLOID ACCUMULATION ARE ASSOCIATED WITH INCREASED FUNCTIONAL CONNECTIVITY IN NON‐DEMENTED ELDERLY SUBJECTS
Author(s) -
Strandberg Olof,
Hahn Andreas,
Stomrud Erik,
Schöll Michael,
Palmqvist Sebastian,
Hansson Oskar
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.664
Subject(s) - default mode network , voxel , pittsburgh compound b , amyloid (mycology) , resting state fmri , neuroscience , alzheimer's disease , psychology , cognitive impairment , medicine , cognition , pathology , disease , radiology
covariates. Results:Using a corrected threshold of .05/30, two components met significance criteria for relationship to both amyloid burden and cognitive decline; a bilateral anterior medial temporal lobe, and a right anterior lateral temporal lobe component. Both were equivalently related to amyloid (r1⁄40.40,p<0.001 and r1⁄40.40,p<0.001), and cognitive decline (r1⁄40.28,p<0.001 and r1⁄40.31;p<0.001). These results compare favorably to FS-defined entorhinal and inferior temporal tau with amyloid (r1⁄40.42,p<0.001 and r1⁄40.39,p<0.001), and PACC decline (r1⁄4-0.26, p1⁄40.001 and r1⁄4 -0.19,p1⁄40.024, respectively). Conclusions: Our results suggest that in older CN the primary association between tau and both amyloid plaques and cognitive decline lies in anterior temporal lobe regions. As expected in a CN cohort, widespread neocortical tau pathology was uncommon. Future analyses with a broader range of impairment and/or larger sample size are expected to result in more distributed patterns of cortical tau. These results also suggest that data driven approaches such as ICA, may prove to be simple and effective tools for measuring and staging tau pathology.