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[P4–488]: THE INTEGRATED ALZHEIMER's DISEASE RATING SCALE (IADRS): FINDINGS FROM THE EXPEDITION3 TRIAL
Author(s) -
Wessels Alette M.,
Matthews Brandy R.,
Dowsett Sherie A.,
Andersen Scott W.,
Siemers Eric R.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.649
Subject(s) - placebo , clinical dementia rating , repeated measures design , rating scale , alzheimer's disease , dementia , cognition , medicine , disease , psychology , drug trial , clinical trial , clinical psychology , psychiatry , developmental psychology , pathology , statistics , mathematics , alternative medicine
annually according to a standardized protocol, the Uniform Data Set. Eligible subjects were aged 60 years or older, cognitively normal but depressed at baseline, and had at least 3 in-person visits from 2005 through 2016. Depression was defined as any two of the five aspects: self-reported depression history which was active in the last 2 years, depression in the last month assessed by Neuropsychiatric Inventory Questionnaire, depressed mood judged by the clinician, active depression diagnosis based on the clinician’s best judgement, or baseline Geriatric Depression Scale score at least 6.MCIwas diagnosed if one didn’t have dementia but had cognitive complaint not normal for his or her age, and had cognitive decline but essentially normal functional activities. Those who progressed from normal to dementia were assumed to have passed through MCI. Time-dependent Cox proportional hazard models examined the association between self-reported antidepressant use and risk of MCI. Results:Out of 669 eligible participants, 488 reported antidepressant use at least once. Of the antidepressant users, 126 (25.82%) eventually developed MCI. A larger number of participants who never used antidepressant eventually developed MCI (61 out of 181, 33.70%). A log rank test indicated that unadjusted MCI-free survival rate was better for antidepressant users (P 1⁄4 0.051). However, after adjusting for covariates and accounting for time-dependent antidepressant use, the relationship no longer attained statistical significance (HR: 0.89; 95% CI: 0.70-1.14; P 1⁄4 0.36).Conclusions:We did not find a significant association between antidepressant use and incident MCI in adjusted models. This result may be partly due to modeling that can account for a participant’s variation in antidepressant use prior to onset of MCI.