[P4–477]: ARE INSULIN RESISTANCE AND CEREBROSPINAL FLUID BIOMARKERS CORRELATED IN PUERTO RICANS WITH MINIMAL COGNITIVE IMPAIRMENT AND EARLY ALZHEIMER's DISEASE?

results for 5 cohorts (ADNI, 3C, FHS, Rotterdam Study and Health ABC) are presented. In a total of 6862 participants (mean age1⁄474; 58% women), 1145 developed incident dementia (714 with AD in a subset of 5864) after amean follow-up of 8.42 years.After adjusting for age and sex, we found that lower levels of plasma Ab 1-42 were associated with a higher risk of dementia and AD (HR for a decrease of one SD1⁄41.20; 95%CI1⁄4[1.10;1.32]; p1⁄42.58 x 10-5; I21⁄448% and HR1⁄41.27; 95%CI1⁄4[1.18;1.37]; p1⁄46.22 x 10-10; I21⁄45%, respectively) with lower heterogeneity than previously reported. Similar results were observed for Ab 1-42/Ab 1-40 ratio (HR1⁄41.22; 95%CI1⁄4 [1.15;1.30]; p1⁄43.54 x 10-11; I21⁄40% and HR1⁄41.27; 95%CI1⁄4 [1.18;1.37]; p1⁄43.56 x 10-10; I21⁄40%, respectively). No significant association was observed for plasma Ab1-40 levels. Conclusions:Using a homogeneous analysis script, we were able to partly address previoulsy reported heterogeneity in associations between plasma Ab levels and incident AD and dementia.We are currently expanding this work by including additional cohorts.