Premium
[P4–461]: ALTERATIONS IN EMOTIONAL VERBAL MEMORY IN SUBJECTIVE COGNITIVE DECLINE AND AMNESTIC MILD COGNITIVE IMPAIRMENT
Author(s) -
Mah Linda,
Anderson Nicole D.,
Herrmann Nathan,
Verhoeff Nicolaas Paul L.G.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.622
Subject(s) - cognition , psychology , recall , audiology , valence (chemistry) , neuropsychology , episodic memory , montreal cognitive assessment , dementia , memory impairment , free recall , cognitive impairment , clinical psychology , disease , developmental psychology , psychiatry , medicine , cognitive psychology , physics , quantum mechanics
progression to Alzheimer’s disease (AD)-type dementia. It remains uncertain in which stage these factors have an influence and how they are associated with AD biomarkers. Therefore, we investigated how risk factors are associated with AD biomarkers in cerebrospinal fluid (CSF) and whether they influence cognitive decline in preclinical AD. Methods:We selected 438 participants from the longitudinal studies at the Knight Alzheimer’s Disease Research Center (mean age: 68.3, SD: 8.5), with a baseline Clinical Dementia Rating (CDR) of 0. All participants had baseline data available for 12 risk factors (Table 1), neuropsychological testing, APOE genotyping and CSF levels of Ab 1-42, tau and p-tau181. We created four groups based on the abnormality of Ab (A +/-) and tau(s) (T +/-) and compared differences in frequency of risk factors among groups using Chi-Square testing. Cognitive decline, with MMSE as outcomes measure, was assessed using linear mixed modeling. All analyses were adjusted for demographics and APOE genotype. Results:The frequencies of risk factors and baseline characteristics for each biomarker group are shown in Table 1. We found a higher frequency of transient ischemic attach (TIA) and a lower frequency of obesity in the T+ groups. Cardiovascular disorders occurred