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[P4–433]: EVALUATION OF ANTI‐INFLAMMATORY AND NEURO‐PROTECTIVE PROPERTIES OF BALANITES AEGYPTIACA BARK AND ZINGIBER OFFICINALE LEAF EXTRACTS ON ALZHEIMER's DISEASE
Author(s) -
Mahdi Onesimus,
Oremosu Ademola
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.593
Subject(s) - neuroprotection , saline , herb , traditional medicine , bark (sound) , medicine , pharmacology , biology , medicinal herbs , ecology
neflamapimod for inhibition of cytokine production (Duffy, 2011), and correlates well with dose/concentration-response seen for episodic memory in the human clinical studies. Conclusions: The findings provide the first evidence that p38a antagonism could be a means to therapeutically target Alzheimer-related endosomal dysfunction. Further, the correlation between in vitro potency of neflamapomid on reversing endolysosomal dysfunction with clinical dose-response suggests that this pharmacological effect, rather than anti-inflammatory activity, may underlie the clinical activity of neflamapimod on episodic memory.