[P4–433]: EVALUATION OF ANTI‐INFLAMMATORY AND NEURO‐PROTECTIVE PROPERTIES OF BALANITES AEGYPTIACA BARK AND ZINGIBER OFFICINALE LEAF EXTRACTS ON ALZHEIMER's DISEASE

neflamapimod for inhibition of cytokine production (Duffy, 2011), and correlates well with dose/concentration-response seen for episodic memory in the human clinical studies. Conclusions: The findings provide the first evidence that p38a antagonism could be a means to therapeutically target Alzheimer-related endosomal dysfunction. Further, the correlation between in vitro potency of neflamapomid on reversing endolysosomal dysfunction with clinical dose-response suggests that this pharmacological effect, rather than anti-inflammatory activity, may underlie the clinical activity of neflamapimod on episodic memory.