Premium
[P4–423]: VARIABILITY IN APOE‐TOMM40‐PVRL2 LOCUS AND OTHER GENOMIC REGIONS CONTRIBUTES TO COGNITIVE PERFORMANCE IN A POPULATION BASED STUDY OF RUSSIAN ELDERLY
Author(s) -
Stepanov Vadim A.,
Makeeva Oksana A.,
Marusin Andrey V.,
Bocharova Anna V.,
Vagaitseva Kseniya V.,
Markova Valentina V.,
Minaycheva Larisa I.,
Buikin Stepan V.,
Zhukova Irina A.,
Zhukova Natalia G.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.583
Subject(s) - montreal cognitive assessment , neurocognitive , medicine , population , effects of sleep deprivation on cognitive performance , single nucleotide polymorphism , type 2 diabetes , cognitive decline , cognition , gerontology , diabetes mellitus , disease , dementia , demography , psychiatry , endocrinology , genetics , biology , genotype , environmental health , gene , sociology
cilia formation) genes. Conclusions: We provide a genome-wide DNA methylation patterns associated with training-induced changes after a 6-month exercise adaptation. Whereas, efforts to understand the implications of these changes are ongoing, future studies should inform the relationships of changes in DNA methylation to mRNA expression in a predominantly AA sample, and correlate such changes with the MCI clinical phenotype.