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[P4–395]: EARLY LIFE STRESS ACCELERATES AMYLOID PATHOLOGY AND COGNITIVE DECLINE IN APPSWE/PS1DE9 MICE, BUT CAN BE RESCUED BY BRIEFLY BLOCKING GLUCOCORTICOID RECEPTORS AT MIDDLE AGE
Author(s) -
Lucassen Paul J.,
Lesuis Sylvie L.,
Weggen Sascha,
Baches Sandra,
Krugers Harm J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.555
Subject(s) - glucocorticoid , glucocorticoid receptor , corticosterone , cognitive decline , hippocampal formation , endocrinology , medicine , psychology , offspring , effects of sleep deprivation on cognitive performance , cognition , hippocampus , neuroscience , disease , hormone , biology , dementia , pregnancy , genetics