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[O5–07–06]: PULSE PRESSURE IN LATE‐LIFE AND ALZHEIMER's AND CEREBROVASCULAR NEUROPATHOLOGY
Author(s) -
Besser Lilah M.,
Nation Daniel A.,
Hughes Timothy M.,
Barlow Nicole,
Kukull Walter A.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.548
Subject(s) - neuropathology , dementia , apolipoprotein e , medicine , cardiology , blood pressure , atrophy , pulse pressure , arteriolosclerosis , disease
adjusted for age, sex, and education. We also described the frequency of neuropathological diagnoses in each group. Results: CDR 0.5 participants (mean age: 72.7610.6) were 47% male, 55% White, and had mean education of 3.862.9 years, while those cognitively normal (mean age: 67.7610.5) were 54% male, 70%White, and had education of 5.464.1 years (Table 1). Compared to cognitively normal, the CDR 0.5 individuals had higher odds of lacunar infarct (OR1⁄43.39, 95%CI1⁄41.199.62) (Table 2). The difference between the groups remained after adjusting for age, sex and educational level. The presence of lacunar infarcts was registered in 16% of the CDR 0.5 group, against 4.5% of cognitively normal individuals (Table 3). Among the 51 participants with CDR1⁄40.5, 84% met criteria for a neuropathological diagnosis, with vascular dementia as the most common diagnosis (n1⁄416; 31%). Among 204 cognitively normal participants (CDR1⁄40), 105 (51%) met criteria for a neuropathological diagnoses, with PART definitive as the most common one (n1⁄459; 29%) (Table 4). Conclusions: This study corroborates findings of series with predominantly Caucasians of high educational level, pointing the role of lacunar infarct in impairing the cognition. As vascular risk factors associated with lacunar infarct are preventable , aggressive measures to reduce these factors may impact the prevalence of cognition associated dysfunction.