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[F5–02–04]: CAN COGNITIVE TRAINING BE USED AS A TOOL TO PROMOTE COGNITIVE RESERVE IN OLDER ADULTS? MEASURING SIMILARITIES AND INTERACTION EFFECTS
Author(s) -
Belleville Sylvie,
Boller Benjamin,
DucharmeLaliberté Gabriel,
Mellah Samira
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.484
Subject(s) - cognitive reserve , cognitive training , cognition , psychology , cognitive decline , modalities , effects of sleep deprivation on cognitive performance , psychological intervention , training (meteorology) , cognitive psychology , neuroscience , medicine , cognitive impairment , dementia , geography , psychiatry , social science , disease , pathology , sociology , meteorology
Study recently funded by the European Commission. Methods:We will focus on literature in cognitively normal, mild cognitive impairment and AD populations that assessed the relationships between several lifestyle measures and AD neuroimaging markers (grey matter volume, glucose metabolism and amyloid deposition). Results:Intellectual enrichment, physical activity, and sleep quality measures have all been shown to be associated with AD biomarkers. Results varied across populations depending on clinical stages, the presence of risk factors (education level or APOE4-carriers) and the specific lifestyle measure and life period. This variation might notably reflect a differential involvement of neuroprotective versus compensatory mechanisms. We will present the Medit-ageing / Silver-Sant e Study as an illustration of translational efforts to use lifestyle modification as a disease risk modifier in preclinical population. This research project proposes 18-month training programmes (English learning or meditation training) as well as a passive control in 130 older participants with AD risk factors. The effects will be assessed on neuroimaging markers as well as blood markers, cognition and sleep measures. This project is also designed to improve our understanding of the intervention mechanisms. Conclusions: Our knowledge on the lifestyle factors that impact AD neuroimaging biomarkers along with possible mechanisms and target populations has improved over the last decade. Although observational studies can further refine our understanding of the mechanisms, time has come to translate our knowledge to training programmes that might prevent or delay brain and cognitive changes leading to Alzheimer’s dementia.