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[F5–02–01]: IDENTIFYING A TASK‐INVARIENT COGNITIVE RESERVE NETWORK
Author(s) -
Stern Yaakov,
Habeck Christian
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.481
Subject(s) - cognition , task (project management) , psychology , expression (computer science) , elementary cognitive task , cognitive psychology , proxy (statistics) , default mode network , effects of sleep deprivation on cognitive performance , computer science , developmental psychology , machine learning , neuroscience , management , economics , programming language
no significant Lewy body pathology despite fulfilling the clinical criteria early. Several cases had fluctuating cognition, while others were presenting visual hallucinations combined with visual impairment. Marked changes of synaptic proteins were found in post-mortem DLB brains, with a pattern distinct from that observed in AD and PDD. Furthermore, we found altered concentrations of synaptic proteins in the CSF of patients with PD that were associated with both cognitive and motor symptoms. We are currently measuring these proteins in the CSF in a larger group of prospectively followed PD and DLB patients. Conclusions: Clinical DLB criteria have acceptable accuracy but need improvement. The pattern of synaptic protein changes, possibly together with structural and functional imaging, may provide a potential for further improving diagnostic accuracy and prognostic prediction of DLB.