Premium
[O4–07–06]: IN VIVO SPREADING PATHWAYS OF TAU AND AMYLOID ACCUMULATION AND ITS GENETIC UNDERPINNINGS
Author(s) -
Sepulcre Jorge,
Grothe Michel J.,
Sperling Reisa A.,
Johnson Keith
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.459
Subject(s) - temporal lobe , neuroscience , posterior cingulate , biology , cortex (anatomy) , psychology , cerebral cortex , posterior parietal cortex , epilepsy
adults with significant memory concerns (SMC), and 14 older adults with early mild cognitive impairment (EMCI). Amyloid positivity was defined as mean cortical [F]Florbetapir SUVR > 1.10. Pre-processed [F]Flortaucipir scans were downloaded from LONI and processed using standard techniques. Briefly, scans were co-registered to the closest timepoint structural MRI, normalized to standard space, and intensity normalized to mean cerebellar crus uptake to create SUVR images. Regional [F]Flortaucipir from the inferior temporal lobe, frontal lobe, parietal lobe, and global cortex were extracted from subject-specific regions of interest generated from Freesurfer. Partial Pearson correlation and linear regression models were used to evaluate the relationship of the ECog with mean [F]Flortaucipir SUVR in the target regions and on a voxelwise level (p<0.001 (uncorrected); k1⁄450 voxels), covaried for age and sex. Results:Significant associations between both self and informant ECog scores and [F]Flortaucipir SUVR were observed (Figure 1). Notably, the self-based memory concerns were associated with tau load predominantly in the frontal cortex and medial temporal regions, while the informant-based concerns were more strongly associated with precuneus and lateral parietal tau load (Figure 1C). However, informant-based concerns were associated with more widespread regions than self-based concerns on voxel-wise analysis (Figure 1B). Conclusions: The association between subjective concerns and tau deposition suggests an important role of tau pathology in the early stages of disease and that involvement of different brain regions underlie the phenomena detected by the ECog scale. Future longitudinal studies will help to elucidate the timing and source of cognitive concern presentation relative to disease and pathological progression.