Premium
[O4–07–02]: LOWER WHITE MATTER INTEGRITY IS ASSOCIATED WITH HIGHER AMYLOID DEPOSITION AND RETROSPECTIVE COGNITIVE DECLINE IN OLDER ADULTS WITHOUT DEMENTIA
Author(s) -
Oh Hwamee,
Narkhede Atul,
Razlighi Qolamreza,
Stern Yaakov,
Mayeux Richard,
Manly Jennifer J.,
Brickman Adam M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.455
Subject(s) - dementia , white matter , standardized uptake value , pittsburgh compound b , amyloid (mycology) , cognitive decline , medicine , psychology , diffusion mri , amyloidosis , alzheimer's disease , pathology , disease , positron emission tomography , neuroscience , magnetic resonance imaging , radiology
detected in both middle-aged adults and adults who were amyloid negative at baseline (Figure 1a). The rate of accumulation in lateral OFC and pars orbitalis was associated with deficits in follow-up reasoning performance (but not episodic memory or processing speed), even after restricting to those who were amyloid negative at baseline (Figure 2). In comparison, high precuneus amyloid accumulation was predominately restricted to older, amyloid positive adults (Figure 1b) and was associated with AD-typical deficits in episodic memory. Conclusions: These findings support the use of the OFC and penumbral regions as markers of the earliest stages of amyloid accumulation, and provide evidence that even at this early stage, negative consequences of amyloid accumulation may already be apparent.