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[O4–07–01]: EARLY AMYLOID ACCUMULATION AND ITS COGNITIVE CONSEQUENCES IN HEALTHY ADULTS
Author(s) -
Farrell Michelle E.,
Chen Xi,
Park Denise C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.454
Subject(s) - precuneus , posterior cingulate , amyloid (mycology) , cognitive decline , cognition , dementia , neuroscience , medicine , psychology , pathology , disease
with histological changes including doublecortin staining and BrdU labeling, indicative of neurogenesis. Furthermore, the effects of young plasma were long-lived, with histological and behavioral changes evident weeks after dosing. Conclusions: The plasma proteome provides a novel source of therapeutics that may be of benefit in disorders involving cognition, including Alzheimer’s disease. The ability of human plasma to have long term effects involving mechanisms such as neurogenesis indicate the disease modifying potential of such therapeutics.