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[O4–04–05]: CEREBRAL MICROBLEEDS AND AMYLOID BURDEN: THE MAYO CLINIC STUDY OF AGING
Author(s) -
GraffRadford Jonathan,
Przybelski Scott A.,
Lesnick Timothy G.,
Rabinstein Alejandro,
Flemming Kelly,
Brown Robert D.,
Mielke Michelle M.,
Spychalla Anthony J.,
Vemuri Prashanthi,
Lowe Val,
Knopman David S.,
Petersen Ronald C.,
Jack Clifford R.,
Kantarci Kejal
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.440
Subject(s) - cerebral amyloid angiopathy , medicine , odds ratio , intracerebral hemorrhage , logistic regression , confidence interval , pittsburgh compound b , population , cardiology , alzheimer's disease , dementia , disease , subarachnoid hemorrhage , environmental health
estimated total intracranial volume, followed by stepwise linear regression models, including lobar [F]AV-1451 binding and age, across the total sample. Results:AD patients had significant increased parietal, occipital and temporal [F]AV-1451 binding compared to controls and MCI (p<0.001) and frontal [F]AV1451 binding compared to controls (p<0.05). Parietal and occipital WMH were significantly higher in AD compared to controls (p<0.05). Across the total sample, global [F]AV-1451 binding correlated with total WMH (r1⁄40.36,p1⁄40.027). Regional partial correlations between [F]AV-1451 binding and WMH were significant for the parietal (r1⁄40.37,p1⁄40.023), temporal (r1⁄40.45,p1⁄40.005) and occipital (r1⁄40.43,p1⁄40.008) lobes. Stepwise linear regression indicated that increased parietal [F]AV1451 binding predicted parietal WMH independent of age (F(2,41)1⁄413.05,p<0.001,R1⁄40.40). Conclusions: We demonstrate the association between tau pathology and WMH in vivo, particularly in the parietal lobe. These findings provide support to post-mortem studies suggesting a role of tau pathology in the pathogenesis of WMH (McAleese et al., 2015). O4-04-05 CEREBRAL MICROBLEEDS AND AMYLOID BURDEN: THE MAYO CLINIC STUDY OFAGING Jonathan Graff-Radford, Scott A. Przybelski, Timothy G. Lesnick, Alejandro Rabinstein, Kelly Flemming, Robert D. Brown, Michelle M. Mielke, Anthony J. Spychalla, Prashanthi Vemuri, Val Lowe, David S. Knopman, Ronald C. Petersen, Clifford R. Jack Jr., Kejal Kantarci, Mayo Clinic, Rochester, MN, USA; Mayo Clinic College of Medicine, Rochester, MN, USA. Contact e-mail: Graff-Radford.Jonathan@ mayo.edu