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[O4–04–04]: [ 18 F]AV‐1451 PET IMAGING OF TAU PATHOLOGY PREDICTS WHITE MATTER HYPERINTENSITIES IN HEALTHY AGING, MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE: THE NIMROD STUDY
Author(s) -
Gabel Silvy,
Mak Elijah,
Cervenka Simon,
Jones P Simon,
Surendranathan Ajenthan,
BevanJones William Richard,
Passamonti Luca,
Rodriguez Patricia Vazquez,
Su Li,
Williams Guy B.,
Arnold Robert,
Firbank Michael J.,
Rowe James B.,
O'Brien John T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.439
Subject(s) - hyperintensity , white matter , medicine , frontotemporal lobar degeneration , alzheimer's disease , voxel , fluid attenuated inversion recovery , nuclear medicine , pathology , psychology , magnetic resonance imaging , neuroscience , dementia , radiology , disease , frontotemporal dementia
and retrospective neuropsychological data from all patients were collected to investigate the retrospective cognitive decline. A linear mixed effects model was used to determine the effects of amyloid, tau, and vascular burden on cognitive decline independently or synergistically. Results: Mean follow-up periods were 4.38 years. Higher amyloid burden was associated with faster cognitive decline in attention, language, visuospatial, memory, frontal functions. Patients with tau braak stage 3 showed faster cognitive decline in all cognitive domains, not in memory function compared to patients with tau braak stage 2, whereas higher vascular burden was associated with faster decline only in calculation score. Significant interactions between amyloid and tau burden were found to be associated with faster decline in all cognitive domains, tau and vascular burden in attention, frontal and visuospatial function, amyloid and vascular burden in COWAT supermarket and calculation score. Amyloid, tau, and vascular burdens also synergistically affected attention, visuospatial and frontal functions. Conclusions: In SVCI patients, amyloid, tau and vascular burden, independently or interactively, contributed to longitudinal cognitive decline. Especially, amyloid and tau burden rather than vascular burden are more associated with cognitive decline.