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[O4–01–03]: TIME‐VARYING RENAL METABOLIC FACTORS ASSOCIATED WITH COGNITIVE DECLINE IN CHRONIC KIDNEY DISEASE: THE BRINK STUDY
Author(s) -
Murray Anne
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.419
Subject(s) - medicine , kidney disease , renal function , cognitive decline , cognition , dialysis , verbal memory , trail making test , gerontology , neuropsychology , physical therapy , disease , dementia , psychiatry
Never abusers had significantly higher NPI-Q scores and more items endorsed than remote abusers for each CDR stage, except CDR1⁄43 which had a small N(Never Abusers N1⁄41040 vs. Any Abuse N1⁄474). CDR-SB did not differ significantly between Never Abusers and those with history of abuse. Conclusions: Our results associate alcohol abuse with increased and more severe NPI-Q behavioral symptoms. Remote abusers exhibit more symptoms than never-abusers, supporting the hypothesis that alcohol abuse is associated with long-lasting behavioral symptoms. However, Alcohol abuse history does not appear to change functional socres based on CDR-SB. The NACC database is funded by NIA/NIH Grant U01 AG016976.