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[O3–10–05]: SUMMATIVE EFFECTS OF VASCULAR RISK FACTORS ON THE PROGRESSION OF ALZHEIMER'S DISEASE
Author(s) -
Fuh JongLing,
Lee WeiJu,
Liao YiChu,
Hsu JungLung,
Wang ShuuJiun
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.361
Subject(s) - medicine , cardiology , cognitive decline , diabetes mellitus , disease , body mass index , dementia , endocrinology
outcomes. Results: In ADNI, higher hippocampal atrophy was associated with greater baseline systolic ((r, p value); 0.2, p1⁄40.004) and pulse pressure (0.2, p1⁄40.007) in MCIs; no associations were found in controls. In NACC, higher baseline systolic BP was associated with lower baseline MMSE in MCIs (-0.23, <0.001); falling MMSE was predicted by falling systolic (0.35, p<0.001) and pulse pressure (0.34, p1⁄40.001). Conversely, in AD patients, lower MMSEs were associated with lower systolic (0.10, p<0.001), diastolic (0.06, p1⁄40.05), and pulse pressure (0.08, p1⁄40.01). Conclusions: These results suggest whilst high BP may be associated with AD development, falling BP may be important in the mid-late AD stages; MCIs with falling BP were more likely to worsen on MMSE, and AD subjects with low systolic BP more likely to have lower baseline MMSEs. Further work is required to understand whether this could inform AD management and prevention strategies.