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[O3–09–03]: MICROGLIAL ACTIVATION IS ASSOCIATED WITH HIGHER GREY MATTER DENSITY AND HIPPOCAMPAL VOLUME IN MCI SUBJECTS
Author(s) -
Daniela Femminella Grazia,
Dani Melanie,
Wood Melanie,
Fan Zhen,
Calsolaro Valeria,
Mizoguchi Ruth,
Atkinson Rebecca A.,
Edginton Trudi,
Waldman Adam,
Hinz Rainer,
Brooks David J.,
Edison Paul
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.352
Subject(s) - grey matter , hippocampal formation , statistical parametric mapping , hippocampus , neuroscience , voxel , pathology , nuclear medicine , pittsburgh compound b , psychology , chemistry , medicine , magnetic resonance imaging , cognitive impairment , cognition , radiology , white matter
Registration between MR images and histological sections allowed us to study critical parameters associated with plaques detection: size, compactness and iron load of plaques. Results: Histological evaluations revealed that patterns of amyloid plaques are similar in APPSL/PS1M146L, APP/PS1dE9 and human brains while they strikingly differ in other mice models. Compact amyloid plaques were always well detected by in vivo or ex vivo Gd-stained MRI unless they measured less than 40 mm. Diffuse plaques and intracellular amyloid deposits were never detected. Evaluation of iron depositions suggested that iron is important but not necessary for plaque detection by Gd-Stained MRI. Conclusions: We demonstrated that the ability to detect amyloid plaques with Gd-stained MR is strikingly different in the various mice models of amyloidosis or in humans. We also showed for the first time that Gd-stained MRI can detect amyloid plaques in post mortem human brains.