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[O3–07–04]: ACTUAL MEMORY DECLINE MEDIATES THE EFFECT OF AMYLOID BURDEN ON SUBJECTIVE MEMORY IN COGNITIVELY NORMAL ADULTS
Author(s) -
Chen Xi,
Farrell Michelle E.,
Park Denise C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.341
Subject(s) - psychology , metamemory , anxiety , episodic memory , developmental psychology , audiology , cognition , clinical psychology , cognitive psychology , neuroscience , medicine , psychiatry , metacognition
HTN-Other group (p1⁄4.008) and those on non-BBB-crossing ARBs (p1⁄4.05). There were no group differences in brain volume. Conclusions:Hypertensive participants demonstrated worse baseline memory and executive function, and greater memory decline over 3 year follow up compared to normotensives, unless they were ARBs users, who showed preserved memory compared to those on other antihypertensive drugs. Users of BBB-crossing ARBs showed superior memory performance over time compared to other antihypertensive drug users and had less WMH volume. Findings demonstrate that ARBs, especially those of the BBB-crossing variety, are associated with greater memory preservation and lessWMHvolume, when compared to other antihypertensive medications.