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[O3–06–03]: THE IMPACT OF AMYLOID AND TAU PATHOLOGY ON THE DEVELOPMENT OF SUBTLE COGNITIVE CHANGES IN PERSONS WITHOUT DEMENTIA
Author(s) -
Jansen Willemijn J.,
Ossenkoppele Rik,
Visser Pieter Jelle
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.334
Subject(s) - dementia , cognition , biomarker , psychology , amyloid (mycology) , alzheimer's disease , episodic memory , medicine , cognitive decline , tau pathology , memory clinic , cognitive impairment , snap , disease , gerontology , pathology , audiology , psychiatry , biology , biochemistry , computer graphics (images) , computer science
SemanticMemory performance (b1⁄4-0.32, p1⁄40.020) while IT tau was not a significant predictor of Semantic Memory performance (b1⁄40.14, p1⁄40.304). Conversely, higher IT tau was associated with worse Episodic Memory (b1⁄4-0.36, p1⁄40.010) but Ab was not a significant predictor for Episodic Memory performance (b1⁄4-0.09, p1⁄40.519). Conclusions: The observed relationship between Semantic Memory and Ab reaffirms the specificity of semantic processing declines to AD. However, the minimal relationship between Semantic Memory and IT tau suggests that the anatomy underlying semantic processing may be more reliant on a distributed neocortical network. In addition, although Semantic andEpisodicMemory are correlated, these findings suggest their degradation in relation to AD pathology may be distinct.