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[O3–03–03]: TAU PATHOLOGY AND GRAY MATTER ATROPHY CONTRIBUTE TO COGNITIVE IMPAIRMENT IN ALZHEIMER's DISEASE
Author(s) -
Bejanin Alexandre,
Schonhaut Daniel R.,
La Joie Renaud,
Kramer Joel H.,
Baker Suzanne L.,
Sosa Natasha,
Ayakta Nagehan,
Cantwell Averill,
Janabi Mustafa,
Lauriola Mariella,
O'Neil James P.,
GornoTempini Marilu,
Miller Zachary A.,
Rosen Howard J.,
Miller Bruce L.,
Jagust William J.,
Rabinovici Gil D.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.316
Subject(s) - atrophy , cognition , psychology , neuroscience , voxel based morphometry , pittsburgh compound b , mediation , pathology , medicine , white matter , cognitive impairment , magnetic resonance imaging , radiology , political science , law
and executive function and cluster 4 (N1⁄414), who had impairment across all 4 domains, manifested neurodegeneration (MRI>FDG) throughout the brain. All clusters showed global amyloid burden (Figure 3). Conclusions:We identified several cognitive clusters among amnestic EOAD ADNI subjects. In addition to the pure amnestic and globally impaired variants, we also found a visuospatial and a language/executive variant suggesting phenotypic heterogeneity in this rare form of AD. The pattern of atrophy and hypometabolism in each cluster was in agreement with the observed cognitive phenotype.