Premium
[F3–02–01]: A SHEEP IN WOLF'S CLOTHING: WHY EPIDEMIOLOGIC RESEARCH ON DEMENTIA TELLS US MORE ABOUT CHILD DEVELOPMENT THAN ABOUT ALZHEIMER'S DISEASE
Author(s) -
Glymour Maria,
Jones Richard N.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.266
Subject(s) - dementia , disease , cognition , psychology , early childhood , gerontology , vulnerability (computing) , alzheimer's disease , medicine , developmental psychology , clinical psychology , psychiatry , pathology , computer security , computer science
sectional estimates with the exception of CSF measures of soluble tau (Table). Conclusions:Using longitudinal data spanning the presympomatic-symptomatic stages, this study supports and refines current models of AD progression. At least 25 years before the onset of symptoms there is period of approximately 10 years of linear increases of b-amyloidosis, followed by a period of approximately 10 years of precuneus hypometabolism and initial brain atrophy, and lastly a period of nearly 5 years before clinical decline where cognition begins to fail. CSF measures of soluble tau are elevated as early as 14 years prior to estimated symptom onset, but appear to decline significantly near the onset of symptoms. Together, these findings clarify the periods of expected changes in ADAD and where prevention therapies may be most effective.