Premium
[O2–11–05]: CORTICAL REGIONS UNDERLYING COGNITIVE RESERVE EFFECTS IN ELDERLY INDIVIDUALS ARE CHARACTERIZED BY A DISTINCT MOLECULAR ARCHITECTURE
Author(s) -
BartrésFaz David,
GonzálezEscamilla Gabriel,
VaquéAlcázar Lídia,
VallsPedret Cinta,
Ros Emilio,
Grothe Michel J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.208
Subject(s) - neocortex , cognition , gene expression , gene expression profiling , gene , effects of sleep deprivation on cognitive performance , biology , psychology , neuroscience , genetics
connections between default and dorsal attention, and noncognitive rs-fcMRI nodes, were associated with higher cognitive reserve (Fig B). Intra-network connections were strongest within the salience network. While connectivity and cognitive reserve relationships were consistent and statistically significant across analyses, these associations were relatively weak. Conclusions: Greater functional connectivity in cognitive networks and across a subset of inter-network connections was associated with greater cognitive reserve, independent of Ab burden. These results support the hypothesis that these connectivity measurements reflect neural reserve capacity. Coupled with prior findings that higher connectivity predicts less cognitive decline over time, these results suggest higher connectivity in individuals with higher cognitive reserve may partly underlie their resilience to AD-related cognitive decline. O2-11-05 CORTICAL REGIONS UNDERLYING COGNITIVE RESERVE EFFECTS IN ELDERLY INDIVIDUALS ARE CHARACTERIZED BYA DISTINCT MOLECULAR ARCHITECTURE