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[O2–11–03]: PREDICTING PROGRESSION IN PRE‐DEMENTIA STAGES OF ALZHEIMER's DISEASE WITH A NEUROIMAGING MEASURE OF COGNITIVE RESERVE
Author(s) -
Loenhoud Anita C.,
Flier Wiesje M.,
Wink Alle Meije,
Groot Colin,
Twisk Jos W.R.,
Berckel Bart N.M.,
Barkhof Frederik,
Scheltens Philip,
Ossenkoppele Rik
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.206
Subject(s) - dementia , alzheimer's disease neuroimaging initiative , cognitive reserve , neuroimaging , medicine , atrophy , cognitive decline , proportional hazards model , psychology , oncology , clinical dementia rating , cognition , alzheimer's disease , biomarker , disease , neuroscience , biochemistry , chemistry
25-item version. We performed partial correlation and stepwise multiple linear regression analysis across the whole cohort. Results: Subjects’ mean age was 69.5 (SD 8.0) years old, and mean years of education was 11.5 (SD 4.7). We found significant positive association of both past, especially early-life, and current CA with ADsignature region CMglu. Stepwise regression analysis demonstrated that among CAs of all the lifetime periods, only early-life CA survived. Such association between early-life CA and CMglu was still significant even after controlling global Ab burden. No significant association was found between past CA (i.e early-life plus midlife) and global Ab retention. Current CA was negatively associated with Ab retention, but the association disappeared after additionally controlling AD-signature region CMglu, suggesting mediating effect of neurodegeneration. Conclusions: The findings suggest that higher CA in early-life including both childhood and early adulthood can be protective against late-life AD-related neurodegeneration process. In terms of AD prevention, this could imply that cognitive activities before midlife is more important than midlife or late-life activities. Reversely, greater Ab burden may reduce current CA by increasing AD-specific neurodegeneration in the elderly.