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[O2–10–04]: ABNORMAL PERCEPTION OR THOUGHT CONTENT IS A RISK TO ALZHEIMER's DISEASE DEVELOPMENT AMONG MILD COGNITIVE IMPAIRMENT: THE JAPANESE ALZHEIMER's DISEASE NEUROIMAGING INITIATIVE COHORT STUDY
Author(s) -
Yokoi Yuma,
Takano Harumasa,
Nakagome Kazuyuki,
Matsuda Hiroshi
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.201
Subject(s) - apathy , dementia , hazard ratio , psychology , disease , cohort , cognition , depression (economics) , alzheimer's disease neuroimaging initiative , alzheimer's disease , neuroimaging , confidence interval , clinical psychology , psychiatry , audiology , medicine , economics , macroeconomics
regression suggested that a one unit increase in SCD doubled the risk of being in the Ab FLR+/striatal Ab+ group in comparison with Ab FLR(p1⁄4.0005). Conclusions:SCD was found to be associated with both neocortical and striatal Ab, however, SCD was found to be most salient in more advanced stages of preclinical amyloidosis. These findings support growing evidence that both high neocortical and striatal Ab is indicative of the later stages of preclinical Alzheimer’s disease.