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[O2–07–02]: ASSOCIATION OF MULTIMORBIDITY WITH NEURODEGENERATION AND BRAIN AMYLOID LOAD IN COGNITIVELY NORMAL SUBJECTS
Author(s) -
Mendes Aline,
Tezenas du Montcel Sophie,
Cavedo Enrica,
Lista Simone,
Hampel Harald,
Dubois Bruno,
Epelbaum Stéphane
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.181
Subject(s) - medicine , neuroimaging , neurodegeneration , standardized uptake value , positron emission tomography , disease , oncology , psychiatry , nuclear medicine
appearing white matter volume (B 0.08 95% CI 3.288E-0060.00,p1⁄40.046) and premorbid cognition with total brain volume (B1⁄40.09 95% CI 0.00-0.001,p1⁄40.03). Adjustments were not made for multiple testing. Conclusions:Childhood SES and IQ are independently associated with infarcts and brain volume in the 7 to 9 decades. The direction of effect on WMH and total cSVD score was consistent with a published meta-analysis. The effect sizes and potential impact of these findings suggest that these associations should be assessed further in larger samples in different populations.