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[O1–11–06]: EXPLORING THE RELATIONSHIP BETWEEN ANAEMIA AND ALZHEIMER's DISEASE
Author(s) -
Winchester Laura,
NevadoHolgado Alejo J.,
Lovestone Simon
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.099
Subject(s) - cognition , disease , dementia , cognitive decline , medicine , mendelian randomization , oncology , physiology , bioinformatics , biology , genetics , gene , psychiatry , genetic variants , genotype
MCI or AD (b1⁄4 0.76, p 1⁄40.038, n1⁄4840). Furthermore, rs2273647-T carriers who eventually developed MCI or AD demonstrated significantly less memory decline (p 1⁄4 0.04, n1⁄4361). Lastly, rs2273647-T was associated with lower SMEK1 expression, indicating a functional role for this variant (p1⁄40.03, n1⁄4217). Conclusions:A variant in SMEK1, rs2273647, has a protective effect against PCC [F] FDG decline, conversion to AD and memory decline, suggesting an important role for this variant in AD vulnerability. Interestingly, SMEK1 is involved in longevity, gluconeogenesis and DNA repair. Given the protective effect of the minor allele of rs2273647, SMEK1 should be considered as an important gene in future AD research.