[O1–11–04]: TOPMED WHOLE GENOME SEQUENCE (WGS) ASSOCIATIONS WITH BRAIN MRI MEASURES IN THE FRAMINGHAM STUDY

University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA; Indiana University Network Science Institute, Bloomington, IN, USA; Harvard Medical School, Boston, MA, USA; Brigham and Women’s Hospital, Boston, MA, USA; Columbia University Medical Center, New York, NY, USA; Broad Institute, Cambridge, MA, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA; Duke University, Durham, NC, USA; Saarland University Medical Center, Homburg, Germany; Mayo Clinic, Rochester, MN, USA; Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, M€olndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M€olndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M€olndal, Sweden; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Memory Clinic, Sk ane University Hospital, Malm€o, Sweden; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malm€o, Sweden; Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Hospital, Philadelphia, PA, USA; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA; University of Pennsylvania, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Case Western Reserve University, Cleveland, OH, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA; Columbia University, New York, NY, USA; John P. Hussman Institute for Human Genomics, University of MiamiMiller School ofMedicine,Miami, FL, USA; University of Miami, Miami, FL, USA; Boston University School of Public Health, Boston, MA, USA; Boston University School of Medicine, Boston, MA, USA; VA Puget Sound Health Care System, Seattle, WA, USA; University of Washington, Seattle, WA, USA; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Alzheimer’s Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain; Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Department of Neurology, University of Navarra School of Medicine, Pamplona, Spain; Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Washington University in St Louis, St Louis, MO, USA; Brigham Young University, Provo, UT, USA; Knight Alzheimer Disease Center, Saint Louis, MO, USA; Hope Center for Neurological Disorders, Saint Louis, MO, USA. Contact e-mail: demingy@wustl.edu