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[O1–10–03]: BIOMARKERS OF INFLAMMATION IN ALZHEIMER's DISEASE
Author(s) -
Heslegrave Amanda J.,
Janelidze Shorena,
Heywood Wendy E.,
Hallqvist Jenny,
Schott Jonathan M.,
Mills Kevin,
Stomrud Erik,
Zetterberg Henrik,
Hansson Oskar
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.090
Subject(s) - osteopontin , cohort , cerebrospinal fluid , medicine , prospective cohort study , pathology , dementia , alzheimer's disease , inflammation , disease , gastroenterology , biomarker , cohort study , chemistry , biochemistry
(mean 77.376 8.75 s.d. years), gender (39% male), and education (mean 15.74 6 8.46 s.d. years), did not differ between subjects diagnosed with normal cognition, mild cognitive impairment, or dementia. Adjusted multivariate logistic regression models demonstrated age as a nonsignificant confounder of GCA in the analysis (OR 1.03; 95% CI 0.99 – 1.07; p1⁄40.13). In contrast to age effects, moderate to severe MTA (OR 2.91; 95%CI 1.4 – 6.02; p<0.05) and WMH (OR 11.29; 95% CI 5.17 – 24.62; p<0.001) significantly increased the odds of moderate to severe GCA in our sample. Conclusions:Moderate to severe GCA seen on brain imaging studies was strongly associated with WMH (CVD) and to a lesser extent MTA (AD). Such atrophy should not be routinely attributed to the sequelae of normal aging without ruling out underlying brain disease. Such understanding may help direct appropriate diagnosis and treatment strategies for those undergoing evaluation for memory complaints or more significant cognitive decline.