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[O1–10–02]: CEREBROVASCULAR DISEASE AND ALZHEIMER's DISEASE, BUT NOT AGING, ARE ASSOCIATED WITH MODERATE TO SEVERE GLOBAL CEREBRAL ATROPHY SEEN ON CLINICAL BRAIN IMAGING STUDIES
Author(s) -
Jicha Gregory A.,
AlJanabi Omar,
Bahrani Ahmed,
Abner Erin L.,
Panuganti Pradeep,
Murphy Ronan,
Bardach Shoshana,
CabanHolt Allison M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.089
Subject(s) - dementia , atrophy , hyperintensity , logistic regression , confounding , disease , cerebral atrophy , medicine , clinical dementia rating , cognition , cognitive decline , alzheimer's disease , psychology , magnetic resonance imaging , cardiology , psychiatry , radiology
only (Table 3). There were no group differences in baseline cognitive performance; however, Stages 1 and 2 exhibited steeper memory decline compared to Stage 0 (Figure 1). Only Stage 2 exhibited steeper executive functioning decline (p < .01; Figure 2). The tau+ only group did not differ significantly from Stage 0 on 6 of 7 measures. Baseline age moderated the relationship between biomarker group and time; older age at study entry was associated with steeper rates of decline for Stage 1 only. Conclusions:In this latemiddle-aged cohort, abnormality in both Ab and tau was associated with decline across memory and executive functioning domains, whereas Ab+