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[O1–01–02]: MICROBLEEDS ARE ASSOCIATED WITH DEPRESSIVE SYMPTOMS IN ALZHEIMER's DISEASE
Author(s) -
Leeuwis Annebet E.,
Prins Niels D.,
Benedictus Marije R.,
Hooghiemstra Astrid M.,
Scheltens Philip,
Biessels Geert Jan,
Barkhof Frederik,
Flier Wiesje M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.034
Subject(s) - hyperintensity , geriatric depression scale , depression (economics) , medicine , dementia , memory clinic , cohort , population , disease , cardiology , depressive symptoms , magnetic resonance imaging , psychiatry , cognition , radiology , macroeconomics , environmental health , economics
memory and global cognition scores (Figure 2), higher CSF concentrations of several pro-inflammatory cytokines (Figure 3), and both lower CSF ab1-42 (R 1⁄40.703) and higher total tau (R1⁄40.441). IL-1 receptor, IL-12, and IL-18 mediated the effects of the Kyn/5-HT ratio on affect measures. A higher Kyn/5-HT ratio was also related to less grey matter volume (Figure 4A) and glucose metabolism (Figure 4B) across the hippocampus, precuneus, and prefrontal cortex. Conclusions: Increased Kyn and decreased 5-HT are strongly related to neural, affective, and cognitive outcomes relevant to major depression and AD. Neuroinflammation may mediate the pathogenesis of Kyn-related depressive symptoms.