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[P2–336]: DIFFERENTIAL EFFECTS OF EARLY AND LATE‐LIFE EXPERIENCES ON AMYLOID DEPOSITION VERSUS NEURODEGENERATION
Author(s) -
ArenazaUrquijo Eider M.,
Gonneaud Julie,
Ourry Valentin,
Flores Robin,
Landeau Brigitte,
Eustache Francis,
Jagust William J.,
Chetelat Gael
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.990
Subject(s) - orbitofrontal cortex , psychology , temporal cortex , temporal lobe , neuropsychology , cognition , neuroscience , audiology , medicine , prefrontal cortex , epilepsy
more impaired language function compared to all other AD groups (F(3)1⁄46.29, p<.01; Figure 1), while memory was relatively preserved in ε2 carriers compared to ε4/ε4 carriers (F(3)1⁄42.67, p1⁄4.05). Voxelwise contrasts against controls revealed relative sparing of the medial temporal lobe in ε2 compared to ε4 carriers (p<.05, family-wise error corrected; Figure 2). Similar analyses using a less stringent threshold (p<.001, uncorrected; Figure 3) revealed that ε2 carriers displayed i) an atrophy pattern that was mostly restricted to temporoparietal regions compared to wider neocortical involvement in other groups, and ii) left>right asymmetry. Conclusions: The observed atrophy pattern in ε2 carriers (i.e. left>right asymmetry and relatively spared medial temporal lobes) matches their neuropsychological profile with prominent language deficits and relatively preserved memory performance. These results help to elucidate differences in regional vulnerability across APOE genotypes and better understand clinical heterogeneity in AD.